The Cubs won the World Series in 2016.
Dexter Fuller played a pivotal role from start to finish.
Fowler, who was unsigned when spring training opened that year, appeared close to signing a three-year deal with the Orioles.
The deal fell apart and Fowler joined the Cubs on a one-year contract after the 2015 season after turning down a one-year qualifying offer of $15.8 million.
In a memorable scene, the center fielder went to the spring training camp in Mesa, Ariz., and told his former teammates that he was coming back.
“I owed it to the guys to tell them first,” Fowler said. “This is what my heart is.”
Fowler hit a World Series leading home run in 7 games that year. Cubs beat the Indians 8-7 in 10 innings to end their 108-year championship drought.
After the 2016 season, Fowler left the Cubs and never returned, signing a five-year, $82.5 million contract with the Cardinals.
He retired on Tuesday at the age of 36.
“Here it is,” Fowler wrote on Twitter. “I’m hanging up my cleats.”
Fowler played for the Cubs from 2015-16 and hit .261/.367/.427 with 30 home runs, 94 RBI, 186 runs and 33 stolen bases.
Over 14 seasons with the Rockies, Astros, Cubs, Cardinals and Angels, Fowler slashed .259/.358/.417 with 127 homers and 517 RBI.
“After winning the World Series in Chicago, standing on the field with wet and icy tears in my eyes,” Fowler wrote on social media. “I am eternally grateful. I am proud to look back on my career knowing that I played the game the right way and did everything I could to make a positive impact beyond winning.”
Right-handers Tyler Duffy and Jordan Holloway signed minor league contracts and were invited to spring training with the Cubs.